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@article{Abu_Awhin_Ozedu_2023, title={EVALUATION OF CARDIOVASCULAR DISEASE RISK FACTORS IN DIABETIC RATS ADMINISTERED ETHANOL EXTRACT OF Cucumis sativus FRUIT.}, volume={4}, url={https://ajhse.org/index.php/ajhse/article/view/405}, DOI={10.52417/ajhse.v4i1.405}, abstractNote={<p>It is estimated that by the year 2030, the number of persons with diabetes mellitus (DM) would increase to 366 million. Diabetes mellitus is primarily defined by the level of hyperglycemia which causes micro- and macro-vascular damage. This study evaluated cardiovascular disease risk factors in diabetic rats administered ethanol extract of <em>Cucumis sativus</em> fruit. Male Wistar rats (n = 25, mean weight = 215 ± 15 g) were used. The rats were randomly assigned to five groups (5 rats per group): normal control, diabetic control, metformin, 200 mg/kg body weight (BWT) extract and 300 mg/kg BWT extract groups. Diabetes mellitus was induced via intraperitoneal injection of streptozotocin (STZ, 50 mg/kg BWT). The diabetic rats were then treated for 21 days with metformin (50 mg/kg BWT) or the extract at doses of 200 and 300 mg/kg BWT, respectively. The results showed that STZ-induced DM significantly increased plasma concentrations of total cholesterol (TC), triacylglycerol (TG), very low-density lipoprotein cholesterol (VLDL-C), low-density lipoprotein cholesterol (LDL-C), atherogenic index of plasma (AIP), atherogenic coefficient (AC) and cardiac risk ratio (CRR), but it significantly reduced high-density lipoprotein cholesterol (HDL-C) (p &lt; 0.05). However, treatment of diabetic rats with ethanol extract of <em>C. sativus</em> fruit led to significant reductions in circulating levels of lipid profile (except HDL-C, which increased) as well as AIP, AC and CRR (p &lt; 0.05). These results suggest that the medicinal plant extract has the capacity to protect against cardiovascular events in diabetic rats.</p&gt;}, number={1}, journal={African Journal of Health, Safety and Environment}, author={Abu , O.D. and Awhin , E.P. and Ozedu, M.E.}, year={2023}, month={Jun.}, pages={108-117} }
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