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EVALUATION OF CARDIOVASCULAR DISEASE RISK FACTORS IN DIABETIC RATS ADMINISTERED ETHANOL EXTRACT OF Cucumis sativus FRUIT.


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  • O.D. Abu Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Nigeria.
  • E.P. Awhin Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Delta State University, Abraka, Delta State, Nigeria.
  • M.E. Ozedu Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Nigeria.
Keywords: Atherogenic coefficient, Cholesterol, Diabetes mellitus, Lipid profile, Streptozotocin.

Abstract

It is estimated that by the year 2030, the number of persons with diabetes mellitus (DM) would increase to 366 million. Diabetes mellitus is primarily defined by the level of hyperglycemia which causes micro- and macro-vascular damage. This study evaluated cardiovascular disease risk factors in diabetic rats administered ethanol extract of Cucumis sativus fruit. Male Wistar rats (n = 25, mean weight = 215 ± 15 g) were used. The rats were randomly assigned to five groups (5 rats per group): normal control, diabetic control, metformin, 200 mg/kg body weight (BWT) extract and 300 mg/kg BWT extract groups. Diabetes mellitus was induced via intraperitoneal injection of streptozotocin (STZ, 50 mg/kg BWT). The diabetic rats were then treated for 21 days with metformin (50 mg/kg BWT) or the extract at doses of 200 and 300 mg/kg BWT, respectively. The results showed that STZ-induced DM significantly increased plasma concentrations of total cholesterol (TC), triacylglycerol (TG), very low-density lipoprotein cholesterol (VLDL-C), low-density lipoprotein cholesterol (LDL-C), atherogenic index of plasma (AIP), atherogenic coefficient (AC) and cardiac risk ratio (CRR), but it significantly reduced high-density lipoprotein cholesterol (HDL-C) (p < 0.05). However, treatment of diabetic rats with ethanol extract of C. sativus fruit led to significant reductions in circulating levels of lipid profile (except HDL-C, which increased) as well as AIP, AC and CRR (p < 0.05). These results suggest that the medicinal plant extract has the capacity to protect against cardiovascular events in diabetic rats.


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Published
2023-06-29
How to Cite
Abu , O., Awhin , E., & Ozedu, M. (2023). EVALUATION OF CARDIOVASCULAR DISEASE RISK FACTORS IN DIABETIC RATS ADMINISTERED ETHANOL EXTRACT OF Cucumis sativus FRUIT. African Journal of Health, Safety and Environment, 4(1), 108-117. https://doi.org/10.52417/ajhse.v4i1.405